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Which of the following would be the most useful reference to learn what combination of antiretroviral agents is currently recommended as a first line therapy to treat HIV infection?

  1. Meta-analyses

  2. A randomized, controlled trial

  3. Clinical practice guidelines

  4. Compendium of Pharmaceuticals and Specialties

The correct answer is: Clinical practice guidelines

Clinical practice guidelines are the most useful reference to learn about the recommended combination of antiretroviral agents for treating HIV infection. These guidelines are developed by experts in the field and regularly updated based on the latest research and evidence. While meta-analyses and randomized controlled trials can provide valuable information, they may not always reflect the current standard of care. The Compendium of Pharmaceuticals and Specialties may provide information on individual drugs, but may not specifically address recommended combinations. Therefore, clinical practice guidelines would be the most reliable and comprehensive source for this information.